I defend the view that the design of the built environment should be a proper part of environmental ethics. An environmentally responsible culture should be one in which citizens take responsibility for the domesticated environments in which they live, as well as for their effects on wild nature. How we build our world reveals both the possibilities in nature and our own stance toward the world. Our constructions and contrivances also objectively constrain the possibilities for the development of a human (...) way of life integrated with wild nature. An environmentally responsible culture should require a built world that reflects and projects care and respect toward nature. (shrink)

In this essay I examine the relevance of the vocabulary of an ethics of care to ecofeminism. While this vocabulary appears to offer a promising alternative to moral extensionism and deep ecology, there are problems with the use of this vocabulary by both essentialists and conceptualists. I argue that too great a reliance is placed on personal lived experience as a basis for ecofeminist ethics and that the concept of care is insufficiently determinate to explicate the meaning of care for (...) nature. (shrink)

This essay articulates the importance of the domesticated landscape for a mature environmental ethics. Human beings are spatial beings, deeply implicated in their relationships to places, both wild and domesticated. Human identity evolves contextually through interaction with a "world." If this world obscures our perception of wild nature, it will be difficult to motivate the social and psychological will to imagine, let alone participate in, a culture that values environmentally responsible conduct. My argument is informed by a pragmatist suspicion of (...) fixed dualisms separating humans from nature, the wild from the domesticated, and the natural from the artificial. Drawing on a variety of sources, the essay calls for greater attention to the ways in which the making of our domesticated worlds can contribute to or undermine our ability to take the intrinsic value of nature seriously. (shrink)

This essay reflects on three strategic visions of how society might develop in the direction of a more environmentally responsible culture. These strategies - green technology, ecocentrism, and civic environmentalism - offer promising elements of what we need. However, each fails in different ways to successfully explain how citizens, caught up in consumerist practices and their supporting belief systems, can be led to take the transformative steps needed to build a culture that engages responsibly and respectfully with the natural environment. (...) This essay aims to acknowledge the contributions of these three approaches, while also critically reflecting on their limitations. The core limitation is the unresolved clash between ecocentrism's focus on the vulnerability of nature's intrinsic value to any anthropogenic intervention and civic environmentalism's focus on the revival of strong civic democracy as a gateway to environmental health. (shrink)

Hunting is a complex phenomenon. l examine it from four different perspectives-animal liberation, the land ethic, primitivism, and ecofeminism-and find no moral justification for sport hunting in any of them. At the same time, however, I argue that there are theoretical flaws in each of these approaches. Animal liberationists focus too much on the individual animal and ignore the difference between domestic and wild animals. Leopold’s land ethic fails to come to terms with the self-domestication of humans. I argue that (...) the holism of the land ethic does not in itself justify hunting as a human act of predation appropriate to the demands of wild biotic communities. Primitivists, such as Paul Shepard and Ortega y Gasset, mistakenly argue that hunting is an essential part of human nature and hence part of a healthy return to a natural way of life. Their argument marginalizes women’s relations to nature. Finally, I take seriously the ecofeminist claim that sport hunting is a symptom ofpatriarchy’s fixation on death and violence, although I criticize the more radical claim that women are closer to nature than men. Hunting should be investigated within the broader context of patriarchal social relations between men and women. As an act of violence it constitutes one element of a cultural matrix which is destructive to hoth women and nature. (shrink)

This chapter contains sections titled: Notes.

Environmental ethics has traditionally focused on a defense of the intrinsic value of animals and wild habitats. However, this ethical project needs to be supplemented by a consideration of the kind of culture that can take such an ethical point of view seriously. This essay argues that one component of an environmentally responsible culture is its domesticated environment. How we construct the domesticated environment has an impact on our perception of our own identities and our relations to wild nature. If (...) we care about wild nature, we must also care about the domesticated environment in which we live our lives. This essay contributes to an ethical reflection on the need to overcome the traditional dualism between domesticated and wild, built and natural that permeates environmental ethical thinking. (shrink)

Argumentation as the public exchange of reasons is widely thought to enhance deliberative interactions that generate and justify reasonable public policies. Adopting an argumentation-theoretic perspective, we survey the norms that should govern public argumentation and address some of the complexities that scholarly treatments have identified. Our focus is on norms associated with the ideals of correctness and participation as sources of a politically legitimate deliberative outcome. In principle, both ideals are mutually coherent. If the information needed for a correct deliberative (...) outcome is distributed among agents, then maximising participation increases information diversity. But both ideals can also be in tension. If participants lack competence or are prone to biases, a correct deliberative outcome requires limiting participation. The central question for public argumentation, therefore, is how to strike a balance between both ideals. Rather than advocating a preferred normative framework, our main purpose is to illustrate the complexity of this theme. (shrink)

This is an annotated translation of the "King Dohäs," a work by the Indian Tantric sage Saraha. It is sub-titled "A Study in the History of Buddhist Thought." The first part is commentary by the translator on "The Tradition about Saraha and His Works," "The Teaching of the Dohäs," and "Existence versus Essence." The second part is the song itself, only nine pages. The third part is two commentaries, one by the Nepalese scholar sKye-med bde-chen and the other by (...) the Tibetan Lama Karma Phrin-las-pa. The original texts are not given though two sample pages are given for the sake of satisfying curiosity about the form of the books, etc. Because the translation is interspersed with terms taken from modern existential philosophy, the average reader and even the Buddhist scholar will have difficulty with the work. It is best suited for someone who is familiar with existential works and who would like to see the terminology applied to Buddhism.--P. J. H. (shrink)

The volume presents essays on the philosophical explanation of the relationship between body and soul in antiquity from the Presocratics to Galen. The title of the volume alludes to a phrase found in Plato, Aristotle and Plotinus, referring to aspects of living behaviour involving both body and soul, and is a commonplace in ancient philosophy, dealt with in very different ways by different authors.

Background: We aimed to determine the smallest changes in health-related quality of life (HRQoL) scores in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 and the Brain Cancer Module (QLQ-BN20), which could be considered as clinically meaningful in brain cancer patients. Materials and methods: World Health Organisation performance status (PS) and mini-mental state examination (MMSE) were used as clinical anchors appropriate to related subscales to determine the minimal clinically important differences (MCIDs) in HRQoL (...) change scores (range 0-100) in the QLQ-C30 and QLQ-BN20. A threshold of 0.2 standard deviation (SD) (small effect) was used to exclude anchor-based MCID estimates considered too small to inform interpretation. Results: Based on PS, our findings support the following integer estimates of the MCID for improvement and deterioration, respectively: physical (6, 9), role (14, 12), and cognitive functioning (8, 8); global health status (7, 4(star)), fatigue (12, 9), and motor dysfunction (4(star), 5). Anchoring with MMSE, cognitive functioning MCID estimates for improvement and deterioration were (11, 2(star)) and for communication deficit were (9, 7). Estimates with asterisks were <0.2 SD and were excluded from our MCID range of 5-14. Conclusion: These estimates can help clinicians evaluate changes in HRQoL over time, assess the value of a health care intervention and can be useful in determining sample sizes in designing future clinical trials. (shrink)

Although numbers as Volume 4, this is the second of the Complete Works to appear, following_ The History of King Richard III_. The Latin text is based on the editions of 1516, 1517, and 1518, fully collated and with the variant readings; the parallel English text is a thoroughly revised version of the translation by G. C. Richards. Also included are the letters on the book exchanged by More and his friends, their tributes, and the marginal glosses of the (...) early editions. The text is followed by a commentary on the relation of _Utopia_ to its own age and as it has been interpreted by scholars. The editors' Introduction included an outline of the genesis and composition of _Utopia_, edited by Father Surtz, will also appear in the Yale Paperbound format. Father Surtz is professor of English at Loyola University, and Mr. Hexter is professor of history at Yale University. Previously announced. (shrink)

Transplantation research on samples and organs from deceased donors in England, Wales and Northern Ireland is under threat. The key problems relate to difficulties encountered in gaining consent for research projects, as distinct from consent to donation for clinical transplantation. They are due partly to the terms of the Human Tissue Act 2004 (the 2004 Act), and partly to its interpretation by the Human Tissue Authority (HTA). They include excessive interaction with donor representatives regarding ‘informed consent’ to research projects, uncertainty (...) as to the scope and duration of a donor's ‘authority’ over an organ, and restrictions caused by the apparent need for licensing of transplantation research under the 2004 Act, combined with lack of certainty, or guidance, as to the distinction between ‘research’, which requires a licence, and ‘service development’, which does not. In our view this confusion hinders and deters Specialist Nurses for Organ Donation in approaching donor representatives and discussing possible research projects with them. It has also, as we have reported elsewhere, led to abandonment of research projects for fear of liability, despite both Research Ethics Committee (REC) approval and donor consent. Such problems do not seem to occur under the transplant laws of most other comparable jurisdictions. The Transplantation Ethics Symposium, ‘The ethics of organ retrieval: goals, rights and responsibilities’, hosted by the MRC Centre for Transplantation at King's College London in December 2010, revealed that many senior clinicians and researchers, administrators, and lawyers are both unclear and in disagreement concerning the effects of the 2004 Act and the extent to which it is adhered to or ignored in practice. In this paper we examine the difficulties encountered and suggest solutions based on a less restrictive interpretation of the 2004 Act, or, more probably, a regulatory change under its authority. We propose that, in the long term, a law which includes consent for REC-approved research within the general consent for organ donation and transplantation seems preferable to the present system, both ethically and in practical terms. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

This collection of original essays examines the relationship between women and religion in the history of political thought broadly conceived. This theme is a remarkably revealing lens through which to view the Western philosophical and poetical traditions that have culminated in secular and egalitarian modern society. The essays also give highly analytical accounts of the manifold and intricate relationships between religion, family and public life in the history of political thought, and the various ways in which these relationships have manifested (...) themselves in pagan, Jewish, Christian and post-Christian settings. (shrink)